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" DNA nanotechnology for bioanalysis: from hybrid DNA nanostructures to functional devices "
/ editors, Giuseppe Arrabito, Liqian Wang.
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Central Library of the Kurdistan University
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| Material Type
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Latin Book
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| Record Number
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217011
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| Doc. No
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6016
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| Language of Document
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English
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| Title & Author
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DNA nanotechnology for bioanalysis: from hybrid DNA nanostructures to functional devices\ / editors, Giuseppe Arrabito, Liqian Wang.
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| Publication Statement
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New Jersey: : World Scientific, , [2018]
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| Page. NO
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xviii, 197 pages: : illustrations (some color).
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| ISBN
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9781786343796 (hc : alk. paper)
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Contents; Dedication; Foreword; Preface; About the Authors; Chapter 1 Nanotechnology and the Unique Role of DNA; 1.1 Introduction; 1.2 The DNA Molecule; 1.2.1 The double helical B-form; 1.2.2 Alternative DNA forms; 1.2.3 Physical and chemical properties of the DNA; 1.3 DNA as Building Block of Self-assembled Nanostructures; 1.4 Functionalization of DNA Nanostructures; 1.4.1 DNA as a recognition motif; 1.4.2 Synthesis of DNA-protein conjugates; 1.4.2.1 Covalent coupling; 1.4.2.2 Non-covalent coupling. 1.5 Dynamic DNA Motifs; References; Chapter 2 DNA as Building Material at the Nanoscale: From Concepts to Software-aided Design; 2.1 Basic Concepts of Design; 2.2 The Two "Schools" of DNA Design; 2.3 The Multi-stranded Approach; 2.3.1 The first immobile junction designed by SEQUIN; 2.3.2 Tile-to-tile assembly; 2.3.3 Platonic and Archimedean tilings; 2.3.4 Single-stranded tiles; 2.4 Scaffold-based Designs; 2.4.1 Monolayer DNA origami; 2.4.2 Space-filled DNA origami; 2.4.3 Wireframe DNA origami. 2.5 DNA Aptamers: From Basics to Applications; References; Chapter 3 DNA Sensors for the Detection of Biomolecules and Biochemical Conditions; 3.1 Introduction; 3.2 Construction of DNA Sensors; 3.2.1 Top-down fabrication of DNA sensors; 3.3 Signal Transduction Mechanisms; 3.3.1 Fluorescence-based sensing; 3.3.1.1 Förster resonance energy transfer; 3.3.2 Plasmonics-based sensing; 3.3.3 DNA nanopore-based sensing; 3.4 Detection of Nucleic Acids; 3.5 Detection of Proteins; 3.6 Detection of Enzymes. 3.7 Detection of Biochemical Conditions and Small Molecules; 3.8 Conclusion and Future Perspective; Acknowledgements; References; Chapter 4 DNA Nanostructures in Cell Biology and Medicine; 4.1 Introduction; 4.2 Cell-SELEX for Cellular Detection; 4.3 Single Cell Manipulation by DNA-directed Protein Immobilization; 4.3.1 DNA-directed immobilization; 4.3.2 Dip-pen nanolithography coupled with DDI for single cells interaction arrays; 4.3.3 High-throughput patterning methodologies for single cells interaction arrays; 4.4 How to Get into Cells. 4.4.1 Phagocytosis; 4.4.2 Pinocytosis; 4.4.3 Macro-pinocytosis; 4.4.4 Clathrin-mediated endocytosis; 4.4.5 Caveolae-mediated endocytosis; 4.4.6 Clathrin- and caveolin-independent endocytosis; 4.5 DNA Nanostructures in Cellular Environment; 4.5.1 DNA structures in cell lysates; 4.5.2 DNA structures in serum; 4.6 DNA Carriers for Drug Delivery; 4.7 Conclusion and Perspectives; References; Chapter 5 Targeting G-quadruplex DNA as Potential Anti-cancer Therapy; 5.1 Introduction; 5.2 Structural Details; 5.3 Biological Involvement.
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| Abstract
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This book is intended for non-specialists and students, presenting a unique introduction to the field of DNA nanotechnology. The primary focus is on the extraordinary advantages of specificity and sensitivity obtained by integrating DNA nanostructures in bioanalytical devices. DNA Nanotechnology for Bioanalysis provides a concise and rigorous description for the fabrication of various types of functional nanostructures by optimized software-aided high-yield synthesis. Following this is the explanation of methods to decorate these nanostructures with molecules such as proteins, metal nanoparticles or bioorganic moieties covalently bonded onto DNA via self-assemblage processes. Also provided is a concise review on non-canonical DNA structures (such as G-quadruplexes) and their targeting by small molecules for applications in pharmacology. Finally, it describes the exciting applications of DNA nanostructures in life sciences and nanomedicine, including ultraspecific molecular delivery, control of cell behavior, analysis of cell lysate and DNA-based nano-tools for super-resolution sub-cellular imaging.
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| Subject
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DNA--Biotechnology.
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Nanobiotechnology.
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| Added Entry
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Arrabito, Giuseppe, Editor
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Wang, Liqian, Editor
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| publication status
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e
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| Keyword
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DNA.Biotechnology of DNA.Nanobiotechnology.
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